Estimates of food intake and body weight gain were
obtained in obese (ob/ob) mice from 7 to 56 days of
age. Milk intake wasestimated daily from 7 to 21 days of
age; there were no differences between
obese
and lean mice. From 14 to 21 days of age, obese mice
gained morebody weight than lean mice. At 21 days of age,
the carcasses of obese micecontained about twice as much
fat as the carcasses of lean mice did, whereas the
protein content was not different. Mice were weaned
at 21days of age, and individually fed a stock diet or a
high-fat diet. During the first several days after weaning,
obese males consumed less food than did the lean males.
After approximately 28 to 35 days of age, obese mice
consumed more food and gained more weight than lean
mice. At 56 days of age, obese mice contained 4 to 5 times
as much body fat as did lean mice,but contained
significantly less body protein than lean mice. For
the 5 week post-weaning period, obese mice converted 3 to 4
times more dietary energy to body energy than did lean
mice, whereas obese mice consumed only 20 to 40% more energy.
At the same time, obese mice converted only about 70% as
much dietary protein to body protein as did lean mice.
The high-fat diet markedly enhanced the apparent energy
efficiency in obesemice. The present studies suggest
that alterations in energy metabolism,as well as in protein
metabolism, may play an important role in the development of
obesity in these mice. Hyperphagia may be of secondary
importance. J. Nutr. 107: 1715-1723, 1977, if you want to
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Food Intake, Body Weight Gain, and Body Composition of the Young Obese
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